LncRNAs在机械转导中的作用及其与Hippo-YAP信号转导的关联

林思怡; 何欣豫; 王颖; 陈妤; 林爱福

doi:10.1631/jzus.B2300497

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LncRNAs在机械转导中的作用及其与Hippo-YAP信号转导的关联

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Review | Updated：2024-04-07

LncRNAs在机械转导中的作用及其与Hippo-YAP信号转导的关联
Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2024年25卷第4期页码：280-292
Affiliations：

1.College of Medicine, Zhejiang University, Hangzhou 310058, China
2.College of Life Sciences, Zhejiang University, Hangzhou 310058, China
3.Cancer Center, Zhejiang University, Hangzhou 310058, China
4.Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Hangzhou 310058, China
5.International School of Medicine, International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China
6.Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Hangzhou 310058, China
7.Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314100, China
Funds：

the National Natural Science Foundation for Distinguished Young Scholars of China(32225014);the “Lingyan” R&D Research and Development Project(2023C03023);the National Key Research and Development Program of China(2021YFC2700903);the National Natural Science Foundation of China(81672791;81872300);the Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China(LR18C060002);Acknowledgement:
DOI：10.1631/jzus.B2300497
中图分类号：
CSTR：
纸质出版日期： 2024-04-15 ，

收稿日期： 2023-07-10 ，

修回日期： 2023-12-11 ，

林思怡,何欣豫,王颖等.LncRNAs在机械转导中的作用及其与Hippo-YAP信号转导的关联[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(04):280-292.

Siyi LIN, Xinyu HE, Ying WANG, et al. Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(4):280-292.
林思怡,何欣豫,王颖等.LncRNAs在机械转导中的作用及其与Hippo-YAP信号转导的关联[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(04):280-292. DOI： 10.1631/jzus.B2300497.

Siyi LIN, Xinyu HE, Ying WANG, et al. Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(4):280-292. DOI： 10.1631/jzus.B2300497.

摘要

细胞在组织中受到各种机械力的作用，包括静水压力、剪切应力、压缩和张力。这些机械刺激可通过机械感受器或细胞骨架依赖性反应过程转化为生化信号，从而塑造微环境，并维持细胞生理平衡。研究已证实转录共激活因子YAP/TAZ可作为机械转导因子，对细胞表型（如分化和疾病发病）产生动态影响。这种调节功能涉及细胞骨架、核骨架、整合素、局灶黏附蛋白（FA），以及多种信号通路的整合，包括细胞外信号调节蛋白激酶（ERK）、WNT和Hippo信号通路。此外，最新研究表明长链非编码RNA（lncRNA）可作为机械敏感分子在机械转导过程中发挥作用。本综述讨论了YAP/TAZ和lncRNA响应机械刺激的机制，并总结了参与机械转导的关键信号分子。

Abstract

Cells within tissues are subject to various mechanical forces

including hydrostatic pressure

shear stress

compression

and tension. These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes

shaping the microenvironment and maintaining cellular physiological balance. Several studies have demonstrated the roles of Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ) as mechanotransducers

exerting dynamic influence on cellular phenotypes including differentiation and disease pathogenesis. This regulatory function entails the involvement of the cytoskeleton

nucleoskeleton

integrin

focal adhesions (FAs)

and the integration of multiple signaling pathways

including extracellular signal-regulated kinase (ERK)

wingless/integrated (WNT)

and Hippo signaling. Furthermore

emerging evidence substantiates the implication of long non-coding RNAs (lncRNAs) as mechanosensitive molecules in cellular mechanotransduction. In this review

we discuss the mechanisms through which YAP/TAZ and lncRNAs serve as effectors in responding to mechanical stimuli. Additionally

we summarize and elaborate on the crucial signal molecules involved in mechanotransduction.

关键词

YAP/TAZ长链非编码RNA（lncRNA）机械转导F-肌动蛋白

Keywords

YAP/TAZLong non-coding RNA (lncRNA)MechanotransductionF-actin

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