靶向铁死亡和铁自噬：心血管疾病的新靶点？

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靶向铁死亡和铁自噬：心血管疾病的新靶点？

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靶向铁死亡和铁自噬：心血管疾病的新靶点？
Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2024年25卷第1期页码：1-22
Affiliations：

1.Clinical Systems Biology Research Laboratories, Translational Medicine Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2.State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China
3.School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China
4.Quality Management Department, Henan No. 3 Provincial People’s Hospital, Zhengzhou 450052, China
5.Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
6.Center for Translational Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
7.Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
8.Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, China
9.Henan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, China
Funds：

the National Natural Science Foundation of China(82204389;82000454);the Medical Science and Technology Research Project of Henan Province(SBGJ202103079);the Henan Medical Science and Technology Joint Building Program(LHGJ20230283;LHGJ20190236;LHGJ20190227;LHGJ20190092;LHGJ20200310;LHGJ20200284)
DOI：10.1631/jzus.B2300097
中图分类号：
CSTR：

栾一,杨阳,栾莹等.靶向铁死亡和铁自噬：心血管疾病的新靶点？[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(01):1-22.

Yi LUAN, Yang YANG, Ying LUAN, et al. Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(1):1-22.
栾一,杨阳,栾莹等.靶向铁死亡和铁自噬：心血管疾病的新靶点？[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(01):1-22. DOI： 10.1631/jzus.B2300097.

Yi LUAN, Yang YANG, Ying LUAN, et al. Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(1):1-22. DOI： 10.1631/jzus.B2300097.

摘要

心血管疾病（CVDs）在全球范围内是死亡的主要驱动因素。铁是一种必需的微量元素，在多种生物过程中很重要。几十年来，铁对心血管疾病的作用引起了广泛的讨论。由铁介导的细胞死亡方式，即铁死亡，在心肌细胞损伤和心血管疾病中发挥着重要的作用，因此受到广泛关注。此外，铁自噬是诱导铁死亡的上游机制，与心血管疾病密切相关。本文就铁死亡和铁自噬的过程、机制、铁自噬的调控途径和分子靶点进行综述，并总结其对心血管疾病的作用。此外，我们讨论了针对铁自噬诱导的铁死亡调节剂治疗心血管疾病的可能性。总之，本综述将为心血管疾病的病理学机制提供新的见解，并提供一系列潜在治疗靶点。

Abstract

Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

关键词

心血管疾病铁铁死亡铁自噬治疗靶点

Keywords

Cardiovascular diseaseIronFerroptosisFerritinophagyTherapeutic target

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