LncRNA在三阴性乳腺癌诊断和预后中的作用

杨秋辉; 傅烨钦; 王嘉萱; 杨红健; 张喜平

doi:10.1631/jzus.B2300067

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Review | Updated：2024-01-19

LncRNA在三阴性乳腺癌诊断和预后中的作用
Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2023年24卷第12期页码：1123-1140
Affiliations：

1.Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
2.Postgraduate Training Base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou 310022, China
3.Shanxi Medical University, Jinzhong 030600, China
Funds：

the Zhejiang Provincial Natural Science Foundation of China(LBY21H160001)
DOI：10.1631/jzus.B2300067
中图分类号：
CSTR：

杨秋辉,傅烨钦,王嘉萱等.LncRNA在三阴性乳腺癌诊断和预后中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1123-1140.

Qiuhui YANG, Yeqin FU, Jiaxuan WANG, et al. Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(12):1123-1140.
杨秋辉,傅烨钦,王嘉萱等.LncRNA在三阴性乳腺癌诊断和预后中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1123-1140. DOI： 10.1631/jzus.B2300067.

Qiuhui YANG, Yeqin FU, Jiaxuan WANG, et al. Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(12):1123-1140. DOI： 10.1631/jzus.B2300067.

摘要

乳腺癌是一种严重危害女性生命的恶性肿瘤。乳腺癌患者的预后因分子类型而异，与其它亚型相比，三阴性乳腺癌（TNBC）因其恶性程度高、侵袭性强、进展快、易复发、易远处转移、预后差和死亡率高而成为近年来的研究热点。许多研究发现，长链非编码RNAs（lncRNAs）在TNBC的发生、增殖、迁移、复发和化疗耐药性等方面起着重要作用。一些lncRNAs有望成为TNBC诊断和预后判断的生物学标志物，甚至成为治疗的新靶点。本文在PubMed文献检索的基础上，总结了lncRNAs在TNBC中的研究进展，并讨论了它们在TNBC诊断、预后和化疗中的作用，希望为未来的研究提供帮助。

Abstract

Breast cancer is a malignant tumor that seriously endangers women’s lives. The prognosis of breast cancer patients differs among molecular types. Compared with other subtypes, triple-negative breast cancer (TNBC) has been a research hotspot in recent years because of its high degree of malignancy, strong invasiveness, rapid progression, easy of recurrence, distant metastasis, poor prognosis, and high mortality. Many studies have found that long non-coding RNA (lncRNA) plays an important role in the occurrence, proliferation, migration, recurrence, chemotherapy resistance, and other characteristics of TNBC. Some lncRNAs are expected to become biomarkers in the diagnosis and prognosis of TNBC, and even new targets for its treatment. Based on a PubMed literature search, this review summarizes the progress in research on lncRNAs in TNBC and discusses their roles in TNBC diagnosis, prognosis, and chemotherapy with the hope of providing help for future research.

关键词

三阴性乳腺癌（TNBC）长链非编码RNA（lncRNA）诊断预后化疗耐药

Keywords

Triple-negative breast cancer (TNBC)Long non-coding RNA (lncRNA)DiagnosisPrognosisChemotherapy resistance

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