丝素蛋白涂层在生物材料表面修饰中的应用： 生物医学领域的丝绸之路

胡金星; 姜治伟; 张晶; 杨国利

doi:10.1631/jzus.B2300003

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丝素蛋白涂层在生物材料表面修饰中的应用：生物医学领域的丝绸之路

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Reviews | Updated：2023-11-15

丝素蛋白涂层在生物材料表面修饰中的应用：生物医学领域的丝绸之路
Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2023年24卷第11期页码：943-956
Affiliations：

1.Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China
Funds：

the National Natural Science Foundation of China(82101062);the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(2023KY132);the Zhejiang Provincial Key Research and Development Program of China(2021C03113)
DOI：10.1631/jzus.B2300003
中图分类号：
CSTR：

胡金星,姜治伟,张晶等.丝素蛋白涂层在生物材料表面修饰中的应用：生物医学领域的丝绸之路[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(11):943-956.

Jinxing HU, Zhiwei JIANG, Jing ZHANG, et al. Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(11):943-956.
胡金星,姜治伟,张晶等.丝素蛋白涂层在生物材料表面修饰中的应用：生物医学领域的丝绸之路[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(11):943-956. DOI： 10.1631/jzus.B2300003.

Jinxing HU, Zhiwei JIANG, Jing ZHANG, et al. Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(11):943-956. DOI： 10.1631/jzus.B2300003.

摘要

作为一种天然的生物聚合物，丝素蛋白（SF）因其具有极低的免疫原性、可调节的生物降解性和优良的生物相容性而成为了生物医学领域的热门材料。目前，SF在生物工程的应用已经利用了多种技术。大多数文献综述着眼在基于SF的生物材料及其不同的应用形式，如薄膜、水凝胶和支架。当SF用作其他生物医学基底材料上的涂层时也很有利用价值；然而，关于含SF涂层的生物材料的综述较少。因此，本文收集了SF涂层在生物材料表面改性中应用的研究进展，阐述了其在生物材料表面修饰的各种制备方法，并介绍了生物材料表面改性的最新进展。此外，本文还讨论了SF涂层在生物医学领域的广泛应用，包括骨再生、韧带再生、皮肤和黏膜再生、神经再生及口腔种植体表面修饰。SF涂层有利于诱导细胞黏附和迁移，促进羟基磷灰石沉积和基质矿化，抑制Notch信号通路，是一种很有前景的骨再生策略。同时，SF涂层复合支架是韧带损伤后再生的候选材料。SF涂层可以提高基底材料的机械性能，并使敷料材料在皮肤和黏膜再生过程中具有整体稳定性。此外，SF涂层由于其只有介电特性、机械柔韧性和促进血管生成的作用，可以成为一种加速神经再生的潜在材料。SF涂层也是口腔种植体表面改性的一种有效手段，可以促进不同材料种植体周围的成骨。本综述对SF涂层生物材料的改进具有一定参考价值，并且有助于实现未来的临床转化。

Abstract

Silk fibroin (SF) as a natural biopolymer has become a popular material for biomedical applications due to its minimal immunogenicity, tunable biodegradability, and high biocompatibility. Nowadays, various techniques have been developed for the applications of SF in bioengineering. Most of the literature reviews focus on the SF-based biomaterials and their different forms of applications such as films, hydrogels, and scaffolds. SF is also valuable as a coating on other substrate materials for biomedicine; however, there are few reviews related to SF-coated biomaterials. Thus, in this review, we focused on the surface modification of biomaterials using SF coatings, demonstrated their various preparation methods on substrate materials, and introduced the latest procedures. The diverse applications of SF coatings for biomedicine are discussed, including bone, ligament, skin, mucosa, and nerve regeneration, and dental implant surface modification. SF coating is conducive to inducing cell adhesion and migration, promoting hydroxyapatite (HA) deposition and matrix mineralization, and inhibiting the Notch signaling pathway, making it a promising strategy for bone regeneration. In addition, SF-coated composite scaffolds can be considered prospective candidates for ligament regeneration after injury. SF coating has been proven to enhance the mechanical properties of the substrate material, and render integral stability to the dressing material during the regeneration of skin and mucosa. Moreover, SF coating is a potential strategy to accelerate nerve regeneration due to its dielectric properties, mechanical flexibility, and angiogenesis promotion effect. In addition, SF coating is an effective and popular means for dental implant surface modification to promote osteogenesis around implants made of different materials. Thus, this review can be of great benefit for further improvements in SF-coated biomaterials, and will undoubtedly contribute to clinical transformation in the future.

关键词

丝素蛋白涂层表面改性Notch信号通路

Keywords

Silk fibroinCoatingSurface modificationNotch signaling pathway

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