Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals
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Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals
Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals
从酵母和哺乳动物细胞解析聚集体自噬和能量匮乏诱导的自噬
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)Pages: 1-5(2024)
Affiliations:
Department of Biochemistry, and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Siyu FAN, Yingcong CHEN, Weijing YAO, et al. Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals. [J/OL]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 1-5(2024)
Siyu FAN, Yingcong CHEN, Weijing YAO, et al. Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals. [J/OL]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 1-5(2024) DOI: 10.1631/jzus.B2300884.
Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals
Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. Compared to research on nutrient deprivation-induced autophagy
the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited. A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy. Using the model organisms
Saccharomyces cerevisiae
and mammalian cells
we found that cellular reactive oxygen species (ROS)
DNA damage sensor Mec1
and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation. This review aims to provide a concise overview of these research findings.
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