Micropeptides: origins, identification, and potential role in metabolism-related diseases

Yirui LU; Yutong RAN; Hong LI; Jiao WEN; Xiaodong CUI; Xiaoyun ZHANG; Xiumei GUAN; Min CHENG

doi:10.1631/jzus.B2300128

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Review | Updated：2024-01-19

Micropeptides: origins, identification, and potential role in metabolism-related diseases
Micropeptides: origins, identification, and potential role in metabolism-related diseases
微肽：起源、鉴定及其在代谢相关疾病中的作用
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 24, Issue 12, Pages: 1106-1122(2023)
Affiliations：

School of Basic Medicine Sciences, Weifang Medical University, Weifang 261053, China
Funds：
DOI：10.1631/jzus.B2300128
CLC：
CSTR：

卢怡睿,冉雨桐,李宏等.微肽：起源、鉴定及其在代谢相关疾病中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1106-1122.

Yirui LU, Yutong RAN, Hong LI, et al. Micropeptides: origins, identification, and potential role in metabolism-related diseases. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 24(12):1106-1122(2023)
卢怡睿,冉雨桐,李宏等.微肽：起源、鉴定及其在代谢相关疾病中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1106-1122. DOI： 10.1631/jzus.B2300128.

Yirui LU, Yutong RAN, Hong LI, et al. Micropeptides: origins, identification, and potential role in metabolism-related diseases. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 24(12):1106-1122(2023) DOI： 10.1631/jzus.B2300128.

摘要

随着现代测序和生物信息学技术的进展，曾被认为不具有编码功能的基因组已被证实能编码功能性小多肽——微肽（miPs）。尽管miPs的鉴定和分析仍较困难，但miPs已进入了许多研究者的视野。越来越多的miPs被发现在能量代谢、免疫调节和肿瘤生长发育中发挥重要作用。有研究表明，在代谢相关疾病中，miPs可调节糖脂代谢和线粒体功能。本文对miPs来源、鉴定及在代谢相关疾病中的作用和意义进行综述，以期揭示其潜在的临床价值。

Abstract

With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides (miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function. MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.

关键词

能量代谢微肽线粒体非编码RNA（ncRNA）小开放阅读框（sORF）

Keywords

Energy metabolismMicropeptidesMitochondriaNoncoding RNA (ncRNA)Small open reading frame (sORF)

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