OCT4’s role and mechanism underlying oral squamous cell carcinoma

Yuwei DAI; Ziqiong WU; Yitong CHEN; Xinjian YE; Chaowei WANG; Huiyong ZHU

doi:10.1631/jzus.B2200602

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OCT4’s role and mechanism underlying oral squamous cell carcinoma

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Review | Updated：2023-09-13

OCT4’s role and mechanism underlying oral squamous cell carcinoma
OCT4’s role and mechanism underlying oral squamous cell carcinoma
OCT4在口腔鳞状细胞癌发病机制中的作用
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 24, Issue 9, Pages: 796-806(2023)
Affiliations：

1.Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.School of Medicine, Zhejiang University, Hangzhou 310058, China
3.School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
4.Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Disease of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China
Funds：
DOI：10.1631/jzus.B2200602
CLC：
CSTR：

Yuwei DAI, Ziqiong WU, Yitong CHEN, et al. OCT4’s role and mechanism underlying oral squamous cell carcinoma. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 24(9):796-806(2023)
DOI：

Yuwei DAI, Ziqiong WU, Yitong CHEN, et al. OCT4’s role and mechanism underlying oral squamous cell carcinoma. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 24(9):796-806(2023) DOI： 10.1631/jzus.B2200602.

摘要

口腔鳞状细胞癌（OSCC）是一种常见的头颈部恶性肿瘤。由于肿瘤复发率高、颈部淋巴结转移和缺乏有效的全身治疗手段，OSCC在全球最具负面影响的癌症中排名第六。其预后差，死亡率高。八聚体结合转录因子4（OCT4）是Pit-Oct-Unc（POU）家族的成员，是一种关键的重编程因子，在保持胚胎干细胞（ESCs）的多能性和自我更新状态方面具有显著作用。最近的研究表明，OCT4参与维持OSCC癌症干细胞（CSC）的存活，对口腔癌的发生、复发、转移和预后具有深远的影响。因此，我们总结了OCT4的结构、亚型、功能及其在OSCC的发生、发展和预后中的作用。

Abstract

Oral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem cells (ESCs). According to recent studies, OCT4 participates in retaining the survival of OSCC cancer stem cells (CSCs), which has far-reaching implications for the occurrence, recurrence, metastasis, and prognosis of oral carcinogenesis. Therefore, we summarize the structure, subtypes, and function of OCT4 as well as its role in the occurrence, progression, and prognosis of OSCC.

关键词

癌症干细胞（CSC）八聚体结合转录因子4（OCT4）口腔鳞状细胞癌（OSCC）预后信号通路

Keywords

Cancer stem cell (CSC)Octamer-binding transcription factor 4 (OCT4)Oral squamous cell carcinoma (OSCC)PrognosisSignaling pathway

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Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU)

Central Laboratory, Peking University School and Hospital of Stomatology

Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices

Department of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

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