An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509

Miaoping LIN; Zhenzhou TANG; Jiaxi WANG; Humu LU; Chenwei WANG; Yanting ZHANG; Xinming LIU; Chenghai GAO; Yonghong LIU; Xiaowei LUO

doi:10.1631/jzus.ZUSB-D-22-00622-0-lhf-author

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An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509

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An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509
An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509
An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Pages: 1-7(2023)
Affiliations：

1.Institute of Marine Drugs, Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
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DOI：10.1631/jzus.ZUSB-D-22-00622-0-lhf-author
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Miaoping LIN, Zhenzhou TANG, Jiaxi WANG, et al. An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509. [J/OL]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 1-7(2023)
DOI：

Miaoping LIN, Zhenzhou TANG, Jiaxi WANG, et al. An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509. [J/OL]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 1-7(2023) DOI： 10.1631/jzus.ZUSB-D-22-00622-0-lhf-author.

摘要

Abstract

概要: 鉴定了化合物的化学结构。化合物,1,-,5,、,7,和,10,对786-O、SW1990和SW480等3株肿瘤细胞增殖具抑制活性，半抑制浓度IC,50,值为4.3–33.4 μmol/L。化合物emestrin J (,10,)具有一个二硫桥键，还能够显著抑制786-O细胞克隆及迁移，诱导786-O细胞凋亡并阻滞细胞分裂在G2/M期，是一个潜在具抗肿瘤活性的先导化合物。

关键词

巢裸胞壳菌海洋真菌芳香聚酮多硫代二酮哌嗪细胞毒

Keywords

references

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An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509

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Institute of Marine Drugs, Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine

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