Research advances in the function and anti-aging effects of nicotinamide mononucleotide

Min WANG; Yuan CAO; Yun LI; Lu WANG; Yuyan LIU; Zihui DENG; Lianrong ZHU; Hongjun KANG

doi:10.1631/jzus.B2300886

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Review | Updated：2024-09-20

Research advances in the function and anti-aging effects of nicotinamide mononucleotide
Research advances in the function and anti-aging effects of nicotinamide mononucleotide
烟酰胺单核苷酸的功能及其抗衰老作用的研究进展
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 9, Pages: 723-735(2024)
Affiliations：

1.Chinese PLA Medical School, Beijing 100853, China
2.Department of Critical Care Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China
3.Department of Emergency, the Second Hospital of Hebei Medical University, Shijiazhuang 050004, China
4.Department of Biochemistry, Chinese PLA Medical School, Beijing 100853, China
5.Department of Clinical Nutrition, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China
6.Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Department of Nephrology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Funds：
DOI：10.1631/jzus.B2300886
CLC：
CSTR：
Published： 15 September 2024 ，

Received： 07 December 2023 ，

Revised： 10 March 2024 ，
Accepted：

王敏,曹媛,李云等.烟酰胺单核苷酸的功能及其抗衰老作用的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(09):723-735.

Min WANG, Yuan CAO, Yun LI, et al. Research advances in the function and anti-aging effects of nicotinamide mononucleotide. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 25(9):723-735(2024)
王敏,曹媛,李云等.烟酰胺单核苷酸的功能及其抗衰老作用的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(09):723-735. DOI： 10.1631/jzus.B2300886.

Min WANG, Yuan CAO, Yun LI, et al. Research advances in the function and anti-aging effects of nicotinamide mononucleotide. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 25(9):723-735(2024) DOI： 10.1631/jzus.B2300886.

摘要

老龄化和年龄相关疾病已成为全球当代社会面临的重大挑战和沉重负担。解决这些问题是一项势在必行的任务，其目的是延缓衰老过程，并找到与年龄有关的退行性疾病的有效治疗方法。最近的研究强调了烟酰胺腺嘌呤二核苷酸（NAD

）在抗衰老领域的重要作用。经验证明，补充烟酰胺单核苷酸（NMN）可以提高体内NAD

水平，从而改善某些与年龄相关的退行性疾病。NMN的抗衰老机制主要在于其对细胞能量代谢的影响、对细胞凋亡的抑制、对免疫功能的调节和对基因组稳定性的保持，这些共同延缓了衰老进程。本文对NMN抗衰老机制的现有研究进行了批判性的回顾和评价，阐明了当前研究的内在局限性，并提出了抗衰老研究的新途径。

Abstract

Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society. Addressing these concerns is an imperative task

with the aims of postponing the aging process and finding effective treatments for age-related degenerative diseases. Recent investigations have highlighted the significant roles of nicotinamide adenine dinucleotide (NAD

) in the realm of anti-aging. It has been empirically evidenced that supplementation with nicotinamide mononucleotide (NMN) can elevate NAD

levels in the body

thereby ameliorating certain age-related degenerative diseases. The p

rincipal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism

inhibition of cell apoptosis

modulation of immune function

and preservation of genomic stability

which collectively contribute to the deferral of the aging process. This paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN

elucidates the inherent limitations of current research

and proposes novel avenues for anti-aging investigations.

关键词

烟酰胺单核苷酸（NMN）抗衰老能量代谢细胞凋亡DNA修复

Keywords

Nicotinamide mononucleotide (NMN)Anti-agingEnergy metabolismApoptosisDNA repair

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Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University

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Tel：+86-571-87952783 Email：cjzhang@zju.edu.cn
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