Neural substrates for regulating self-grooming behavior in rodents

Guanqing LI; Chanyi LU; Miaomiao YIN; Peng WANG; Pengbo ZHANG; Jialiang WU; Wenqiang WANG; Ding WANG; Mengyue WANG; Jiahan LIU; Xinghan LIN; Jian-Xu ZHANG; Zhenshan WANG; Yiqun YU; Yun-Feng ZHANG

doi:10.1631/jzus.B2300562

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Review | Updated：2024-10-17

Neural substrates for regulating self-grooming behavior in rodents
Neural substrates for regulating self-grooming behavior in rodents
啮齿动物自我梳理行为调控的神经基质
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 10, Pages: 841-856(2024)
Affiliations：

1.State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2.CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100101, China
3.School of Life Sciences, Hebei University, Baoding 071002, China
4.State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
5.Department of Rehabilitation Medicine, Tianjin Huanhu Hospital, Tianjin 300350, China
6.Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100101, China
7.Department of Gastrointestinal Surgery, the People’s Hospital of Zhaoyuan City, Zhaoyuan 265400, China
8.School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China
9.Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 200031, China
10.Ear, Nose & Throat Institute, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 200031, China
11.Clinical and Research Center for Olfactory Disorders, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 200031, China
Funds：
DOI：10.1631/jzus.B2300562
CLC：
CSTR：
Published： 15 October 2024 ，

Published Online： 09 July 2024 ，

Received： 07 August 2023 ，

Revised： 11 December 2023 ，
Accepted：

李关卿,路蝉伊,尹苗苗等.啮齿动物自我梳理行为调控的神经基质[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(10):841-856.

Guanqing LI, Chanyi LU, Miaomiao YIN, et al. Neural substrates for regulating self-grooming behavior in rodents. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(10):841-856.
李关卿,路蝉伊,尹苗苗等.啮齿动物自我梳理行为调控的神经基质[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(10):841-856. DOI： 10.1631/jzus.B2300562.

Guanqing LI, Chanyi LU, Miaomiao YIN, et al. Neural substrates for regulating self-grooming behavior in rodents. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(10):841-856. DOI： 10.1631/jzus.B2300562.

摘要

梳理是一种进化上保守的刻板行为，广泛存在于包括人类在内的各种动物中。梳理行为在动物维持体表清洁、调节体温、去觉醒、减轻压力以及社会行为等方面发挥重要功能。在啮齿类动物中，梳理行为通常可以分为四个连续的阶段，并以从头至尾顺序的方式进行重复刻板动作：从口鼻部到面部，到头部，最后以舔舐躯体结束。梳理行为的发生具有环境依赖性，说明此行为具有适应的重要性。本综述简要总结了啮齿类动物梳理行为涉及的神经基质，并探讨了异常梳理行为表型的存在与神经精神疾病和神经退行性疾病模型的相关性。此外，本文进一步强调指出，在神经精神病学模型中，啮齿类动物的梳理行为可作为测定重复刻板行为的一种可靠测量方法，有望在转化精神病学中应用。本文主要聚焦啮齿动物的自我理毛行为，因受限于篇幅，未对allogrooming（同种动物通过舔舐或以仔细啃咬的方式为另一种动物梳理毛发）与heterogrooming（在特定情况下发生的对另一种动物的梳理行为，如母性行为、性行为、攻击行为或社会行为）展开讨论。

Abstract

Grooming

as an evolutionarily conserved repetitive behavior

is common in various animals

including humans

and serves essential functions including

but not limited to

hygiene maintenance

thermoregulation

de-arousal

stress reduction

and social behaviors. In rodents

grooming involves a patterned and sequenced structure

known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style

beginning from the nose to the face

to the head

and finally ending with body licking. The context-dependent occurrence of grooming behavior indicates its adaptive significance. This review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming phenotypes. We further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models

holding promise for translational psychiatry. Herein

we mainly focus on rodent self-grooming. Allogrooming (grooming being applied on one animal by its conspecifics via licking or carefully nibbling) and heterogrooming (a form of grooming behavior directing towards another animal

which occurs in other contexts

such as maternal

sexual

aggressive

or social behaviors) are not covered due to space constraints.

关键词

梳理刻板行为句法链从头至尾进行神经精神疾病

Keywords

GroomingRepetitive behaviorSyntactic chainCephalocaudal progressionNeuropsychiatric disorders

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