Wireless closed-loop deep brain stimulation using microelectrode array probes

Qianli JIA; Yaoyao LIU; Shiya LV; Yiding WANG; Peiyao JIAO; Wei XU; Zhaojie XU; Mixia WANG; Xinxia CAI

doi:10.1631/jzus.B2300400

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Review | Updated：2024-10-17

Wireless closed-loop deep brain stimulation using microelectrode array probes
Wireless closed-loop deep brain stimulation using microelectrode array probes
基于微电极阵列探针的无线闭环脑深部刺激技术
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 10, Pages: 803-823(2024)
Affiliations：

1.State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China
2.School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
Funds：
DOI：10.1631/jzus.B2300400
CLC：
CSTR：
Published： 15 October 2024 ，

Published Online： 12 February 2024 ，

Received： 05 June 2023 ，

Revised： 25 August 2023 ，
Accepted：

贾千里,刘瑶瑶,吕诗雅等.基于微电极阵列探针的无线闭环脑深部刺激技术[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(10):803-823.

Qianli JIA, Yaoyao LIU, Shiya LV, et al. Wireless closed-loop deep brain stimulation using microelectrode array probes. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(10):803-823.
贾千里,刘瑶瑶,吕诗雅等.基于微电极阵列探针的无线闭环脑深部刺激技术[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(10):803-823. DOI： 10.1631/jzus.B2300400.

Qianli JIA, Yaoyao LIU, Shiya LV, et al. Wireless closed-loop deep brain stimulation using microelectrode array probes. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(10):803-823. DOI： 10.1631/jzus.B2300400.

摘要

脑深部刺激（DBS），包括光刺激和电刺激，对于脑重大疾病发病机理和治疗方法开发的研究具有重要的科学意义。基于植入式微电极阵列（MEA）探针的DBS微系统的发展为原位闭环DBS（CL-DBS）提供了新机遇。闭环DBS可用于监测受损的神经细胞活动，并可根据电生理信号调整刺激参数，以实现对神经细胞活动的精准高效调控。基于MEA探针的CL-DBS微系统虽取得了快速发展，但仍有一些关键问题亟需解决，包括无线通信的安全性、稳定性和电池寿命等。本综述回顾和总结了基于MEA探针的无线CL-DBS微系统的最新进展，并探讨了该技术存在的主要问题和未来发展前景。未来，基于MEA探针的无线CL-DBS技术的不断发展和进步将继续为神经科学和临床神经学带来创新，并为脑重大疾病的治疗提供新策略。

Abstract

Deep brain stimulation (DBS)

including optical stimulation and electrical stimulation

has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously. Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems

key challenges

including excessive wired communication

need to be urgently resolved. In this review

we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field. This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.

关键词

脑深部刺激（DBS）无线闭环脑深部刺激微系统微电极阵列探针光刺激电刺激

Keywords

Deep brain stimulation (DBS)Wireless closed-loop deep brain stimulation (CL-DBS) microsystemMicroelectrode array (MEA) probeOptical stimulationElectrical stimulation

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