从酵母和哺乳动物细胞解析聚集体自噬和能量匮乏诱导的自噬

范思雨; 陈颖聪; 姚伟静; 易聪

doi:10.1631/jzus.B2300884

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从酵母和哺乳动物细胞解析聚集体自噬和能量匮乏诱导的自噬

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Mini-review | Updated：2024-04-07

从酵母和哺乳动物细胞解析聚集体自噬和能量匮乏诱导的自噬
Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2024年页码：1-5
Affiliations：

Department of Biochemistry, and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Funds：

the Zhejiang Provincial Natural Science Foundation of China(LR21C070001);the National Natural Science Foundation of China(32122028;92254307;32070739;32100600)
DOI：10.1631/jzus.B2300884
中图分类号：
CSTR：
网络出版日期： 2024-04-07 ，

收稿日期： 2023-12-05 ，

修回日期： 2024-01-03 ，

范思雨,陈颖聪,姚伟静等.从酵母和哺乳动物细胞解析聚集体自噬和能量匮乏诱导的自噬[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,

Siyu FAN, Yingcong CHEN, Weijing YAO, et al. Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals[J/OL]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,1-5.
范思雨,陈颖聪,姚伟静等.从酵母和哺乳动物细胞解析聚集体自噬和能量匮乏诱导的自噬[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）, DOI：10.1631/jzus.B2300884.

Siyu FAN, Yingcong CHEN, Weijing YAO, et al. Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals[J/OL]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,1-5. DOI： 10.1631/jzus.B2300884.

摘要

作为细胞内重要的物质降解途径，自噬在维持细胞稳态过程中起着至关重要的作用。然而，相较于物质匮乏诱导的自噬，我们对能量匮乏诱导自噬的分子机制和生理病理意义的认识非常有限。因此，我们实验室主要探究细胞如何感知能量匮乏并启动自噬发生。通过酿酒酵母和哺乳动物细胞两种模式生物，我们发现在能量匮乏诱导的自噬发生中，细胞的活性氧（ROS）、DNA损伤感受器Mec1和线粒体有氧呼吸是必需的。本文旨在对这些研究成果进行简要总结，并提出该研究领域今后的重点发展方向。

Abstract

Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. Compared to research on nutrient deprivation-induced autophagy

the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited. A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy. Using the model organisms

Saccharomyces cerevisiae

and mammalian cells

we found that cellular reactive oxygen species (ROS)

DNA damage sensor Mec1

and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation. This review aims to provide a concise overview of these research findings.

关键词

自噬葡萄糖饥饿固态聚集体自噬含TCP1伴侣蛋白亚基2（CCT2）

Keywords

AutophagyGlucose starvationSolid aggrephagyChaperonin-containing TCP-1 subunit 2 (CCT2)

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