三例以癫痫为主要表现的急性草铵膦中毒患者的病例报告

王萍; 宋聪颖; 陆璇; 陆远强

doi:10.1631/jzus.B2300469

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三例以癫痫为主要表现的急性草铵膦中毒患者的病例报告

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Correspondence | Updated：2024-04-07

三例以癫痫为主要表现的急性草铵膦中毒患者的病例报告
Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2024年25卷第4期页码：354-358
Affiliations：

1.Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
2.Zhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, Hangzhou 310003, China
3.Department of Geriatric Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Funds：

the Key Research and Development Program of Zhejiang Province(2019C03076)
DOI：10.1631/jzus.B2300469
中图分类号：
CSTR：
纸质出版日期： 2024-04-15 ，

收稿日期： 2023-06-28 ，

修回日期： 2023-09-03 ，

王萍,宋聪颖,陆璇等.三例以癫痫为主要表现的急性草铵膦中毒患者的病例报告[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(04):354-358.

Ping WANG, Congying SONG, Xuan LU, et al. Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(4):354-358.
王萍,宋聪颖,陆璇等.三例以癫痫为主要表现的急性草铵膦中毒患者的病例报告[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(04):354-358. DOI： 10.1631/jzus.B2300469.

Ping WANG, Congying SONG, Xuan LU, et al. Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(4):354-358. DOI： 10.1631/jzus.B2300469.

摘要

Abstract

草铵膦作为谷氨酸（Glu）的结构类似物，可以不可逆地抑制植物中谷氨酰胺合成酶（GS）和谷氨酸脱羧酶活性，从而阻止谷氨酰胺（Gln）生成，最终导致植物因氮代谢紊乱和细胞内氨积累而死亡。人误服草胺磷后也会出现相应的中毒症状，包括胃肠道症状和神经毒性。草铵膦作为最常见的致癫痫类除草剂，且无特定解毒剂，因此支持性治疗至关重要。在临床诊治过程中，如何及时有效识别草铵膦除草剂引起的神经毒性并提供适当治疗尤为关键。本文介绍了我院三名草铵膦中毒患者的主要症状，其中癫痫是主要的神经表现。随后，通过查阅相关文献，对草铵膦引发神经毒性的相关机制进行了总结，并讨论了神经毒性的预测和检测方法。

关键词

草铵膦癫痫除草剂中毒头部CT

Keywords

references

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