促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能

吴迪

doi:10.1631/jzus.B2300288

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促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能

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Correspondence | Updated：2024-01-19

促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能
Proapoptotic protein Bim regulates the suppressive function of Treg cells
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2023年24卷第12期页码：1180-1184
Affiliations：

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Funds：

the National Natural Science Foundation of China(82172699);the Zhejiang Provincial Natural Science Foundation of China(LY21H100005);the Zhejiang Provincial Medical Health Science and Technology Project (Western Medicine) from Health Commission of Zhejiang Province(2024KY093)
DOI：10.1631/jzus.B2300288
中图分类号：
CSTR：

吴迪.促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1180-1184.

Di WU. Proapoptotic protein Bim regulates the suppressive function of Treg cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(12):1180-1184.
吴迪.促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1180-1184. DOI： 10.1631/jzus.B2300288.

Di WU. Proapoptotic protein Bim regulates the suppressive function of Treg cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(12):1180-1184. DOI： 10.1631/jzus.B2300288.

摘要

调节性T细胞（Treg细胞）是一种特殊的免疫抑制性CD4,+,-T淋巴细胞亚群，具有维持机体免疫稳态的重要作用。有研究证实，促凋亡蛋白Bim参与Treg细胞功能的调控，但是还没有使用条件性敲除小鼠对Bim在Treg细胞中功能研究的报道，且Treg细胞中Bim发挥功能的机制也不清楚。已知Bim在衰老的Treg细胞中丰度下调，然而该过程在Treg细胞衰老过程中的具体作用尚不清楚。本研究中，作者繁育产生,Foxp3,Cre,;,Bim,fl/fl,条件性敲除小鼠，特异性在Treg细胞中敲除,Bim,。,Foxp3,Cre,;,Bim,fl/fl,小鼠可育，但是出现多器官炎性细胞浸润和免疫细胞的过度激活，这表明Bim可以调节Treg细胞免疫抑制功能。,Bim,缺失导致Treg细胞转录组变化，以及,Ctla4,基因和多个信号通路的下调。Treg细胞中,Bim,的缺失可以抑制胆管癌的增殖，并延长胆管癌小鼠的生存期。,Bim,缺失的Treg细胞，不能复现衰老Treg细胞的转录组变化，这表明Bim的下调可能是Treg细胞衰老过程中的下游事件。

Abstract

关键词

调节性T细胞Bim肿瘤免疫治疗免疫系统衰老

Keywords

references

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