基于动物模型的房颤治疗进展

巩倩; 乐萱; 余鹏程; 庄乐南

doi:10.1631/jzus.B2300285

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Review | Updated：2024-02-01

基于动物模型的房颤治疗进展
Therapeutic advances in atrial fibrillation based on animal models
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2024年25卷第2期页码：135-152
Affiliations：

1.Institute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
2.Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
Funds：

the National Key Research and Development Program of China(2021YFA0805902);the National Natural Science Foundation of China(32270884)
DOI：10.1631/jzus.B2300285
中图分类号：
CSTR：

巩倩,乐萱,余鹏程等.基于动物模型的房颤治疗进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(02):135-152.

Qian GONG, Xuan LE, Pengcheng YU, et al. Therapeutic advances in atrial fibrillation based on animal models[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(2):135-152.
巩倩,乐萱,余鹏程等.基于动物模型的房颤治疗进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(02):135-152. DOI： 10.1631/jzus.B2300285.

Qian GONG, Xuan LE, Pengcheng YU, et al. Therapeutic advances in atrial fibrillation based on animal models[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2024,25(2):135-152. DOI： 10.1631/jzus.B2300285.

摘要

心房颤动（Atrial fibrillation, AF）是人类最常见的由持续性心律失常导致的心脏疾病，其发病率随着年龄增长而显著增加。尽管房颤在临床实践中很常见，但其病因和治疗尚不清晰。为了制定有效的治疗策略，必须了解房颤的基本机制，因此建立房颤的动物模型对于探索其发病机制至关重要。虽然自发性房颤在大多数动物中罕见，但近年来一些大型动物模型，特别是猪、狗和马模型，已被证明在推进我们对房颤发病机制认识和开发新的治疗方案方面非常宝贵。本综述旨在对房颤的各种动物模型进行全面讨论，重点介绍每种模型的特征及其在房颤研究和治疗中的效用。本综述为房颤机制提供了宝贵的见解，并可用于评估新型治疗干预措施的有效性和安全性。

Abstract

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia among humans, with its incidence increasing significantly with age. Despite the high frequency of AF in clinical practice, its etiology and management remain elusive. To develop effective treatment strategies, it is imperative to comprehend the underlying mechanisms of AF; therefore, the establishment of animal models of AF is vital to explore its pathogenesis. While spontaneous AF is rare in most animal species, several large animal models, particularly those of pigs, dogs, and horses, have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic options. This review aims to provide a comprehensive discussion of various animal models of AF, with an emphasis on the unique features of each model and its utility in AF research and treatment. The data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

关键词

房颤动物模型治疗

Keywords

Atrial fibrillationAnimal modelTherapeutic

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