一例由2019冠状病毒病(COVID-19)疫苗接种引发的白癜风病例及其胸腺功能障碍的作用机制分析

Denis KUZNETSOV; Oleg kalyuzhin; Andrey MIRONOV; Valery NESCHISLIAEV; Anastasiia KUZNETSOVA

doi:10.1631/jzus.B2300025

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一例由2019冠状病毒病(COVID-19)疫苗接种引发的白癜风病例及其胸腺功能障碍的作用机制分析

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Correspondence | Updated：2024-01-19

一例由2019冠状病毒病(COVID-19)疫苗接种引发的白癜风病例及其胸腺功能障碍的作用机制分析
A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2023年24卷第12期页码：1141-1150
Affiliations：

1.GN. Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology, Moscow 125212, Russia
2.IM. Sechenov First Moscow State Medical University, Moscow 119991, Russia
3.Perm State Pharmaceutical Academy, Perm 614990, Russia
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DOI：10.1631/jzus.B2300025
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Denis KUZNETSOV,Oleg kalyuzhin,Andrey MIRONOV等.一例由2019冠病毒病(COVID-19)疫苗接种引发的白癜风病例及其胸腺功能障碍的作用机制分析[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1141-1150.

Denis KUZNETSOV, Oleg KALYUZHIN, Andrey MIRONOV, et al. A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(12):1141-1150.
Denis KUZNETSOV,Oleg kalyuzhin,Andrey MIRONOV等.一例由2019冠病毒病(COVID-19)疫苗接种引发的白癜风病例及其胸腺功能障碍的作用机制分析[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(12):1141-1150. DOI： 10.1631/jzus.B2300025.

Denis KUZNETSOV, Oleg KALYUZHIN, Andrey MIRONOV, et al. A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2023,24(12):1141-1150. DOI： 10.1631/jzus.B2300025.

摘要

最近，人们发现接种2019冠状病毒病（COVID-19）疫苗后出现了大量并发症，影响心脏、肾脏、胰腺、关节和皮肤。本文结合已报道的11例COVID-19疫苗（主要与信使RNA（mRNA）疫苗有关）接种后白癜风病例的数据和我们自己接种的1例非复制载体疫苗后的白癜风病例，分析探讨了其相关的病理机制。根据常见的原理，自身免疫性病变是通过病毒的抗原表位与某些人类蛋白质之间的分子模拟诱发的。我们认为这一过程的基础是胸腺负选择的破坏，导致自身反应性T细胞迁移到外周。在本文中，我们证实了疫苗和/或感染以及黑素细胞氧化应激是自身免疫反应的主要诱因。在这种情况下，白癜风的发病机制可被视为糖尿病或动脉粥样硬化等多种自身免疫性疾病发病机制的模型。此外，我们概述了一种病理机制，其中黑色素细胞氧化应激、自身反应性T细胞和胸腺功能障碍可作为干预策略的潜在目标。

Abstract

关键词

白癜风2019冠状病毒病疫苗皮质醇去氢表雄酮自身反应性T细胞维生素D3

Keywords

references

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