Growing role of CD40 ligand gene transfer therapy in the management of systemic malignancies besides hepatocellular carcinomas#

Growing role of CD40 ligand gene transfer therapy in the management of systemic malignancies besides hepatocellular carcinomas # # first-author †E-mail:shailendrakapoor@yahoo.com †E-mail:shailendrakapoor@yahoo.com shailendrakapoor@yahoo.com Schaumburg, IL-60195, USA Schaumburg, IL-60195, USA CD40 ligand Squamous cell carcinomas Pulmonary carcinomas Prostate carcinomas Pancreatic carcinomas The article “Cationic liposome-mediated transfection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice” [doi:10.1631/jzus.B0820178] by Jiang et al.( 2009 2009 ) in a recent issue of the Journal of Zhejiang University SCIENCE B was highly thought provoking. The authors have clearly demonstrated the efficacy of CD40 ligand gene therapy in inhibiting the growth of hepatocellular carcinomas. The findings of Jiang et al.( 2009 2009 ) are highly important as they further support and corroborate the rapidly expanding role of CD40 ligand gene therapy in the management of systemic malignancies besides hepatocellular carcinomas. For instance, CD40 ligand gene transfer into cutaneous dendritic cells attenuates tumor growth in dermatological malignancies such as squamous cell carcinoma cell lines (Tomihara et al., 2008 2008 ). Similar attenuation of tumor growth in gastrointestinal tumors, such as pancreatic carcinomas, has been achieved following CD40 ligand gene therapy (Serba et al., 2008 2008 ; Kuhlmann et al., 2008 2008 ). CD40 ligand gene transfection by using adenoviruses has also been successfully used for regressing tumor growth in pulmonary carcinomas (Wu et al., 2007 2007 ). CD40 ligand gene transfection has also been used in controlling tumor growth in other systemic malignancies. For instance, urological cancer cell lines, such as the TRAMP-C2 (prostate carcinoma) cell line, show attenuated tumor growth and size following CD40 ligand gene therapy (Dzojic et al., 2006 2006 ). The above examples have clearly highlighted the importance of the findings of Jiang et al.( 2009 2009 ). Clearly, CD40 ligand gene therapy has a major role to play in the control and management of systemic malignancies and may prove to be a major tool in medicine. References H Dzojic , A Loskog , TH Totterman , M Essand . Adenovirus-mediated CD40 ligand therapy induces tumor cell apoptosis and systemic immunity in the TRAMP-C2 mouse prostate cancer model . Prostate , 2006 . 66 ( 8 ): 831 - 838 . 16491482 DOI: 10.1002/pros.20344 http://doi.org/10.1002/pros.20344 . Adenovirus-mediated CD40 ligand therapy induces tumor cell apoptosis and systemic immunity in the TRAMP-C2 mouse prostate cancer model YF Jiang , J Ma , Y He , YH Zhang , Y Xu , GZ Gong . Cationic liposome-mediated transfection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice . J Zhejiang Univ Sci B , 2009 . 10 ( 1 ): 7 - 13 . 19198017 DOI: 10.1631/jzus.B0820178 http://doi.org/10.1631/jzus.B0820178 . Cationic liposome-mediated transfection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice KF Kuhlmann , DJ Gouma , JG Wesseling . Adenoviral gene therapy for pancreatic cancer: where do we stand? . Dig Surg , 2008 . 25 ( 4 ): 278 - 292 . 18635930 DOI: 10.1159/000145981 http://doi.org/10.1159/000145981 . Adenoviral gene therapy for pancreatic cancer: where do we stand? S Serba , J Schmidt , N Wentzensen , E Ryschich , A Marten . Transfection with CD40L induces tumour suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma . Gut , 2008 . 57 ( 3 ): 344 - 351 . 17675324 DOI: 10.1136/gut.2007.130252 http://doi.org/10.1136/gut.2007.130252 . Transfection with CD40L induces tumour suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma K Tomihara , K Kato , Y Masuta , K Nakamura , H Uchida , K Sasaki , T Tanaka , J Huang , H Hiratsuka , H Hamada . Gene transfer of CD40-ligand to dendritic cells stimulates interferon-gamma production to induce growth arrest and apoptosis of tumor cells . Gene Ther , 2008 . 15 ( 3 ): 203 - 213 . 17989706 DOI: 10.1038/sj.gt.3303056 http://doi.org/10.1038/sj.gt.3303056 . Gene transfer of CD40-ligand to dendritic cells stimulates interferon-gamma production to induce growth arrest and apoptosis of tumor cells JQ Wu , WH Zhao , Y Li , B Zhu , KS Yin . Adeno-associated virus mediated gene transfer into lung cancer cells promoting CD40 ligand-based immunotherapy . Virology , 2007 . 368 ( 2 ): 309 - 316 . DOI: 10.1016/j.virol.2007.07.006 http://doi.org/10.1016/j.virol.2007.07.006 . Adeno-associated virus mediated gene transfer into lung cancer cells promoting CD40 ligand-based immunotherapy 10.1631/jzus.B0950001 2022-01-05 Copyright © 2009, Journal of Zhejiang University Science 2009 Journal of Zhejiang University-SCIENCE B (Biomedicine and Biotechnology) 03 10