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Establishment of a standardized daily behavior collection and analysis system for brain disease models of rhesus and cynomolgus monkeys and its application in autism spectrum disorder
Establishment of a standardized daily behavior collection and analysis system for brain disease models of rhesus and cynomolgus monkeys and its application in autism spectrum disorder
- 恒河猴和食蟹猴脑疾病模型的标准化日常行为采集和分析系统的建立及其在孤独症谱系障碍中的应用
- Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 11, Pages: 972-995(2024)
- Affiliations：
1.National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming650107, China
2.Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming650201, China
3.Department of Physiology, Faculty of Basic Medical Science, Kunming Medical University, Kunming650500, China
4.Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming650500, China
5.University of Chinese Academy of Sciences, Beijing101408, China
- Funds：
DOI：10.1631/jzus.B2400294
CLC：- CSTR：
Published： 15 November 2024 ，
Received： 06 June 2024 ，
Revised： 25 September 2024 ，
- Accepted：
任晓峰,王慧敏,吕小满等.恒河猴和食蟹猴脑疾病模型的标准化日常行为采集和分析系统的建立及其在孤独症谱系障碍中的应用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(11):972-995.
XIAOFENG REN, HUIMIN WANG, XIAOMAN LV, et al. Establishment of a standardized daily behavior collection and analysis system for brain disease models of rhesus and cynomolgus monkeys and its application in autism spectrum disorder. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(11): 972-995.
任晓峰,王慧敏,吕小满等.恒河猴和食蟹猴脑疾病模型的标准化日常行为采集和分析系统的建立及其在孤独症谱系障碍中的应用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(11):972-995. DOI： 10.1631/jzus.B2400294.
XIAOFENG REN, HUIMIN WANG, XIAOMAN LV, et al. Establishment of a standardized daily behavior collection and analysis system for brain disease models of rhesus and cynomolgus monkeys and its application in autism spectrum disorder. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(11): 972-995. DOI： 10.1631/jzus.B2400294.
摘要
复杂脑疾病严重危害人类健康，目前缺乏早期诊断生物标志物和有效的治疗方法。由于人类研究受到伦理的限制，猴模型的建立对解决这些问题至关重要。随着转基因技术的快速发展，一系列脑疾病，尤其是孤独症谱系障碍（ASD）的转基因猴模型已被成功建立。然而，要建立实用、有效的脑疾病模型，并将其应用于疾病机理和治疗研究中，目前还缺乏一个标准的工具，即脑疾病模型猴的日常行为采集和分析系统。因此，我们以行为表型的全面、定量研究为目标，针对模型构建中常用的恒河猴和食蟹猴，建立了一个标准的日常行为采集和分析系统，包括行为数据采集方法和猴日常行为目录（MDBE）。然后，我们以ASD为应用实例，参考广泛用于临床疾病和模型研究的《精神障碍诊断与统计手册》（第五版，修订版）（DSM-5-TR）中的ASD核心临床症状，基于MDBE建立了一个用于ASD猴模型核心临床症状定量评估的子行为目录（ASD猴核心行为目录（MCBE-ASD））。随后，我们通过实验数据证明了该系统的高度可重复性，并比较了不同恒河猴个体间行为模式的差异。
Abstract
Complex brain diseases seriously endanger human health
and early diagnostic biomarkers and effective treatments are currently lacking. Due to ethical constraints on human research
establishing monkey models is crucial to address these issues. With the rapid development of technology
transgenic monkey models of a range of brain diseases
especially autism spectrum disorder (ASD)
have been successfully established. However
to establish practical and effective brain disease models and subsequently apply them to disease mechanism and treatment studies
there is still a lack of a standard tool
i.e.
a system for collecting and analyzing the daily behaviors of brain disease model monkeys. Therefore
with the goal of undertaking a comprehensive and quantitative study of behavioral phenotypes
we established a standard daily behavior collection and analysis system
including behavioral data collection protocols and a monkey daily behavior ethogram (MDBE) for rhesus and cynomolgus monkeys
which are the most commonly used non-human primates in model construction. Then
we used ASD as an application example after referring to the Diagnostic and Statistical Manual of Mental Disorders
Fifth Edition
Text Revision (DSM-5-TR)
which is widely used in clinical disease diagnosis to obtain ASD core clinical symptoms. We then established a sub-ethogram (ASD monkey core behavior ethogram (MCBE-ASD)) specifically for quantitative assessment of the core clinical symptoms of an ASD monkey model based on MDBE. Subsequently
we demonstrated the high reproducibility of the system.
关键词
猴日常行为目录猴行为采集方法恒河猴食蟹猴孤独症谱系障碍（ASD）
Keywords
Monkey daily behavior ethogramMonkey behavior collection protocolRhesus monkeyCynomolgus monkeyAutism spectrum disorder (ASD)
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