Pharmacotherapy for the core symptoms of autism spectrum disorder

Peiying TAN; Xiaolin SHEN; Lizhang ZENG; Xuchu WENG; Hongyan GENG

doi:10.1631/jzus.B2300864

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Review | Updated：2024-12-03

Pharmacotherapy for the core symptoms of autism spectrum disorder
Pharmacotherapy for the core symptoms of autism spectrum disorder
自闭症谱系障碍核心症状的药物疗法
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 11, Pages: 956-971(2024)
Affiliations：

1.Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, South China Normal University, Guangzhou510631, China
2.Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou510631, China
Funds：
DOI：10.1631/jzus.B2300864
CLC：
CSTR：
Published： 15 November 2024 ，

Received： 30 November 2023 ，

Revised： 09 May 2024 ，
Accepted：

谭佩莹,沈晓琳,曾礼漳等.自闭症谱系障碍核心症状的药物疗法[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(11):956-971.

PEIYING TAN, XIAOLIN SHEN, LIZHANG ZENG, et al. Pharmacotherapy for the core symptoms of autism spectrum disorder. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(11): 956-971.
谭佩莹,沈晓琳,曾礼漳等.自闭症谱系障碍核心症状的药物疗法[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(11):956-971. DOI： 10.1631/jzus.B2300864.

PEIYING TAN, XIAOLIN SHEN, LIZHANG ZENG, et al. Pharmacotherapy for the core symptoms of autism spectrum disorder. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(11): 956-971. DOI： 10.1631/jzus.B2300864.

摘要

自闭症谱系障碍（ASD）是一系列以社交功能障碍和刻板行为为特征的神经发育疾病。ASD的病因在很大程度上仍未探明，它的临床表现多种多样，而且严重程度也各不相同。目前，尚无经监管机构批准的药物可有效治疗ASD的核心症状。儿童期和青春期是ASD治疗取得重大成果的关键阶段，因此有必要开发专门针对这两个时期的药物。根据药物的作用靶点和机制，研究发现非典型精神药物、抗炎和抗氧化药物、激素药物、离子通道药物和胃肠道药物能显著改善儿童和青少年的ASD核心症状。此外，比较分析同类药物的疗效和安全性可以确定更好的替代药物，并促进药物的开发。虽然这些药物的有效性和安全性仍需要进一步评估，但它们在临床治疗ASD核心症状方面具有巨大的广泛应用潜力。

Abstract

Autism spectrum disorder (ASD) is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors. The etiology of ASD remains largely unexplored

resulting in a diverse array of described clinical manifestations and varying degrees of severity. Currently

there are no drugs approved by a supervisory organization that can effectively treat the core symptoms of ASD. Childhood and adolescence are crucial stages for making significant achievements in ASD treatment

necessitating the development of drugs specifically for these periods. Based on the drug targets and mechanisms of action

it can be found that atypical psychotropic medications

anti-inflammatory and antioxidant medications

hormonal medications

ion channel medications

and gastrointestinal medications have shown significant improvement in treating the core symptoms of ASD in both children and adolescents. In addition

comparisons of drugs within the same category regarding efficacy and safety have been made to identify better alternatives and promote drug development. While further evaluation of the effectiveness and safety of these medications is needed

they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD.

关键词

自闭症谱系障碍核心症状药物治疗重复行为社交功能障碍

Keywords

Autism spectrum disorder (ASD)Core symptomPharmacotherapyRepetitive behaviorsSocial dysfunction

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Wei CAO

Huiyi LI

Jianhong LUO

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Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University

Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine

Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Hangzhou Normal University

Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare, Hangzhou Normal University

Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University

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