Prefrontal cortical circuits in social behaviors: an overview

Wei CAO; Huiyi LI; Jianhong LUO

doi:10.1631/jzus.B2300743

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Prefrontal cortical circuits in social behaviors: an overview
Prefrontal cortical circuits in social behaviors: an overview
前额叶皮层环路与社交行为概述
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 11, Pages: 941-955(2024)
Affiliations：

1.Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou311121, China
2.Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou310013, China
3.Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou311121, China
4.Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare, Hangzhou Normal University, Hangzhou311121, China
5.Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou310015, China
6.NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou310058, China
Funds：
DOI：10.1631/jzus.B2300743
CLC：
CSTR：
Published： 15 November 2024 ，

Received： 12 October 2023 ，

Revised： 02 January 2024 ，
Accepted：

曹蔚,李慧怡,罗建红.前额叶皮层环路与社交行为概述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(11):941-955.

WEI CAO, HUIYI LI, JIANHONG LUO. Prefrontal cortical circuits in social behaviors: an overview. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(11): 941-955.
曹蔚,李慧怡,罗建红.前额叶皮层环路与社交行为概述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(11):941-955. DOI： 10.1631/jzus.B2300743.

WEI CAO, HUIYI LI, JIANHONG LUO. Prefrontal cortical circuits in social behaviors: an overview. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(11): 941-955. DOI： 10.1631/jzus.B2300743.

摘要

社交是人类和动物基本而复杂的行为，受社会认知和情感相互作用的调控。社交障碍发病率高，同样也是自闭症谱系障碍（ASD）和精神分裂症（SCZ）等神经精神疾病的显著临床特征。尽管有关社交行为神经的基础研究不断增多，但其精确的神经环路机制仍然有待阐明。本文回顾了前额叶皮层（PFC）在调节社交行为中的关键作用及其在社交障碍中的功能改变。大量研究提示：PFC功能障碍可能是以社交缺陷为共同特征的精神疾病发病机制的关键病理节点。此外，本文深入梳理了啮齿类动物内侧PFC（mPFC）与其他皮层区域和皮层下大脑区域的复杂连接，以及这些连接在社交行为调控中的作用。值得注意的是，大量证据强调了mPFC的

-甲基-D-天冬氨酸（NMDA）受体以及小清蛋白阳性中间神经元的正常功能在调控社交行为中的作用。因此，深入解析社交相关的神经环路及其功能，将有助于揭示社交障碍的神经病理机制并指导临床转化研究。

Abstract

Social behaviors are fundamental and intricate func

tions in both humans and animals

governed by the interplay of social cognition and emotions. A noteworthy feature of several neuropsychiatric disorders

including autism spectrum disorder (ASD) and schizophrenia (SCZ)

is a pronounced deficit in social functioning. Despite a burgeoning body of research on social behaviors

the precise neural circuit mechanisms underpinning these phenomena remain to be elucidated. In this paper

we review the pivotal role of the prefrontal cortex (PFC) in modulating social behaviors

as well as its functional alteration in social disorders in ASD or SCZ. We posit that PFC dysfunction may represent a critical hub in the pathogenesis of psychiatric disorders characterized by shared social deficits. Furthermore

we delve into the intricate connectivity of the medial PFC (mPFC) with other cortical areas and subcortical brain regions in rodents

which exerts a profound influence on social behaviors. Notably

a substantial body of evidence underscores the role of

-methyl-D-aspartate receptors (NMDARs) and the proper functioning of parvalbumin-positive interneurons within the mPFC for social regulation. Our overarching goal is to furnish a comprehensive understanding of these intricate circuits and thereby contribute to the enhancement of both research endeavors and clinical practices concerning social behavior deficits.

关键词

前额叶皮层社交行为自闭症谱系障碍精神分裂症小清蛋白阳性中间神经元N-甲基-D-天冬氨酸（NMDA）受体

Keywords

Prefrontal cortex (PFC)Social behaviorAutism spectrum disorder (ASD)Schizophrenia (SCZ)Parvalbumin-positive interneuronN-Methyl-D-aspartate receptor (NMDAR)

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