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Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials
Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials
- 全身或局部辅助使用抗生素在种植体周围炎治疗中的疗效：随机对照临床试验的系统综述和荟萃分析
- Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Pages: 1-13(2024)
- Affiliations：
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou310000, China
- Funds：
DOI：10.1631/jzus.B2300730
CLC：- CSTR：
-
Published Online： 03 December 2024 ，
Received： 18 October 2023 ，
Revised： 01 April 2024 ，
- Accepted：
陆怡凡,鲍思琦,罗洪科等.全身或局部辅助使用抗生素在种植体周围炎治疗中的疗效：随机对照临床试验的系统综述和荟萃分析[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,
YIFAN LU, SIQI BAO, HONGKE LUO, et al. Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials. [J/OL]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 1-13.
陆怡凡,鲍思琦,罗洪科等.全身或局部辅助使用抗生素在种植体周围炎治疗中的疗效：随机对照临床试验的系统综述和荟萃分析[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）, DOI：10.1631/jzus.B2300730.
YIFAN LU, SIQI BAO, HONGKE LUO, et al. Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials. [J/OL]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 1-13. DOI： 10.1631/jzus.B2300730.
摘要
本文通过对随机对照临床试验（RCT）结果进行综述和荟萃（meta）分析，评估全身或局部辅助使用抗生素在种植体周围炎治疗中的疗效。两名研究人员分别独立从三个电子数据库中，筛选符合所有纳入和排除标准的RCT结果的相关文献，并采用meta分析评估种植体留存率（SR）、种植体周袋探诊深度（PPD）、牙槽骨水平（BL）和临床附着水平（CAL）变化的加权平均差异。本文将研究组定义为抗生素组和对照组，并进行亚组分析。最终，7项研究被纳入，包括309例患者（390个种植体）。结果显示，抗生素组的患者在PPD方面表现出显著的改善；亚组分析表明，全身使用抗生素或在非手术治疗中使用抗生素不会显著改变BL。在本综述的研究范围内，无论是通过手术还是非手术方式，辅助使用抗生素都可以改善种植体周围炎治疗中的PPD和SR，在BL和CAL方面也表现出一定程度的效果，但考虑到对照组中缺乏新技术的应用以及目前对抗生素潜在风险的评估受限，医生在临床工作中仍需谨慎选择。
Abstract
This systematic review and meta-analysis considered the results of randomized controlled clinical trials (RCTs) to evaluate the efficacy of systemic or local antibiotic therapy in peri-implantitis. Two independent authors screened publications from three electronic databases to include RCTs meeting all the inclusion and exclusion criteria. A meta-analysis was performed to evaluate the weighted mean differences in survival rate (SR) and changes in pocket probing depth (PPD)
bone level (BL)
and clinical attachment level (CAL). The study cohorts were defined as antibiotic and control groups with subgroups for analysis. Seven studies including 309 patients (390 implants) were considered. Within the limitations of this review
patients in the antibiotic groups exhibited significant improvements in PPD. Subgroup analysis indicated that the administration of systemic antibiotics or the use of antibiotics in non-surgical treatments did not result in a significant alteration in BL. It was established that the addition of antibiotics can ameliorate PPD and SR in the treatment of peri-implantitis
whether through surgical or non-surgical approaches
and also shows moderate performance regarding BL and CAL. Considering the lack of application of new technologies in the control group and the hardship of assessing the potential risks of antibiotics
careful clinical judgment is still necessary.
关键词
种植体周围炎口腔种植体口腔医学微生物学疾病管理荟萃分析
Keywords
Peri-implantitisDental implantOral medicineMicrobiologyDisease managementMeta-analysis
references
Alves CH, Russi KL, Rocha NC, et al., 2022. Host-microbiome interactions regarding peri-implantitis and dental implant loss. J Transl Med, 20:425. https://doi.org/10.1186/s12967-022-03636-9https://doi.org/10.1186/s12967-022-03636-9
Baus-Domínguez M, Bakkali S, Hermida-Cabrera P, et al., 2023. A systematic review and meta-analysis of systemic and local antibiotic therapy in the surgical treatment of peri-implantitis. Antibiotics, 12(7):1223. https://doi.org/10.3390/antibiotics12071223https://doi.org/10.3390/antibiotics12071223
Berglundh T, Armitage G, Araujo MG, et al., 2018. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol, 45(S20):S286-S291. https://doi.org/10.1111/jcpe.12957https://doi.org/10.1111/jcpe.12957
Blanco C, Pico A, Dopico J, et al., 2022. Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial. J Clin Periodontol, 49(1):15-27. https://doi.org/10.1111/jcpe.13564https://doi.org/10.1111/jcpe.13564
Boccia G, di Spirito F, D'Ambrosio F, et al., 2023. Local and systemic antibiotics in peri-implantitis management: an umbrella review. Antibiotics, 12(1):114. https://doi.org/10.3390/antibiotics12010114https://doi.org/10.3390/antibiotics12010114
Carcuac O, Derks J, Charalampakis G, et al., 2016. Adjunctive systemic and local antimicrobial therapy in the surgical treatment of peri-implantitis: a randomized controlled clinical trial. J Dent Res, 95(1):50-57. https://doi.org/10.1177/0022034515601961https://doi.org/10.1177/0022034515601961
Carcuac O, Derks J, Abrahamsson I, et al., 2017. Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial. J Clin Periodontol, 44(12):1294-1303. https://doi.org/10.1111/jcpe.12813https://doi.org/10.1111/jcpe.12813
Cha JK, Lee JS, Kim CS, 2019. Surgical therapy of peri-implantitis with local minocycline: a 6-month randomized controlled clinical trial. J Dent Res, 98(3):288-295. https://doi.org/10.1177/0022034518818479https://doi.org/10.1177/0022034518818479
Chan HL, Lin GH, Suarez F, et al., 2014. Surgical management of peri-implantitis: a systematic review and meta-analysis of treatment outcomes. J Periodontol, 85(8):1027-1041. https://doi.org/10.1902/jop.2013.130563https://doi.org/10.1902/jop.2013.130563
Chen QM, Wang YH, Shuai J, 2023. Current status and future prospects of stomatology research. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(10):853-867. https://doi.org/10.1631/jzus.B2200702https://doi.org/10.1631/jzus.B2200702
Claffey N, Clarke E, Polyzois I, et al., 2008. Surgical treatment of peri-implantitis. J Clin Periodontol, 35(s8):316-332. https://doi.org/10.1111/j.1600-051X.2008.01277.xhttps://doi.org/10.1111/j.1600-051X.2008.01277.x
Darby I, 2022. Risk factors for periodontitis & peri-implantitis. Periodontol 2000, 90(1):9-12. https://doi.org/10.1111/prd.12447https://doi.org/10.1111/prd.12447
Derks J, Tomasi C, 2015. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol, 42(S16):S158-S171. https://doi.org/10.1111/jcpe.12334https://doi.org/10.1111/jcpe.12334
Emanuel N, Machtei EE, Reichart M, et al., 2020. D-PLEX500: a local biodegradable prolonged release doxycycline-formulated bone graft for the treatment for peri-implantitis. A randomized controlled clinical study. Quintessence Int, 51(7):546-553. https://doi.org/10.3290/j.qi.a44629https://doi.org/10.3290/j.qi.a44629
Feres M, Martins R, Souza JGS, et al., 2023. Unraveling the effectiveness of antibiotics for peri-implantitis treatment: a scoping review. Clin Implant Dent Relat Res, 25(4):767-781. https://doi.org/10.1111/cid.13239https://doi.org/10.1111/cid.13239
Figuero E, Graziani F, Sanz I, et al., 2014. Management of peri-implant mucositis and peri-implantitis. Periodontol2000, 66(1):255-273. https://doi.org/10.1111/prd.12049https://doi.org/10.1111/prd.12049
Graziani F, Karapetsa D, Alonso B, et al., 2017. Nonsurgical and surgical treatment of periodontitis: how many options for one disease?Periodontol2000, 75(1):152-188. https://doi.org/10.1111/prd.12201https://doi.org/10.1111/prd.12201
Grusovin MG, Pispero A, del Fabbro M, et al., 2022. Antibiotics as adjunctive therapy in the non-surgical treatment of peri-implantitis: a systematic review and meta-analysis. Antibiotics, 11(12):1766. https://doi.org/10.3390/antibiotics11121766https://doi.org/10.3390/antibiotics11121766
Heitz-Mayfield LJ, Aaboe M, Araujo M, et al., 2018. Group 4 ITI consensus report: risks and biologic complications associated with implant dentistry. Clin Oral Implants Res, 29(S16):351-358. https://doi.org/10.1111/clr.13307https://doi.org/10.1111/clr.13307
Heitz-Mayfield LJA, Mombelli A, 2014. The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants, 29(Suppl):325-345. https://doi.org/10.11607/jomi.2014suppl.g5.3https://doi.org/10.11607/jomi.2014suppl.g5.3
Higgins JPT, Thompson SG, Deeks JJ, et al., 2003. Measuring inconsistency in meta-analyses. BMJ, 327(7414):557-560. https://doi.org/10.1136/bmj.327.7414.557https://doi.org/10.1136/bmj.327.7414.557
Higgins JPT, Altman DG, Gøtzsche PC, et al., 2011. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 343:d5928. https://doi.org/10.1136/bmj.d5928https://doi.org/10.1136/bmj.d5928
Keestra JAJ, Grosjean I, Coucke W, et al., 2015. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res, 50(3):294-314. https://doi.org/10.1111/jre.12221https://doi.org/10.1111/jre.12221
Khoshkam V, Chan HL, Lin GH, et al., 2013. Reconstructive procedures for treating peri-implantitis: a systematic review. J Dent Res, 92(12 Suppl):131S-138S. https://doi.org/10.1177/0022034513509279https://doi.org/10.1177/0022034513509279
Klinge B, Gustafsson A, Berglundh T, 2002. A systematic review of the effect of anti-infective therapy in the treatment of peri-implantitis. J Clin Periodontol, 29(s3):213-225. https://doi.org/10.1034/j.1600-051x.29.s3.13.xhttps://doi.org/10.1034/j.1600-051x.29.s3.13.x
Lee CT, Huang YW, Zhu L, et al., 2017. Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis. J Dent, 62:1-12. https://doi.org/10.1016/j.jdent.2017.04.011https://doi.org/10.1016/j.jdent.2017.04.011
Li ZB, Li K, Ding T, et al., 2022. The effect of nonaugmentative approaches in the surgical treatment of peri-implantitis: a systematic review and network meta-analysis. Int J Oral Maxillofac Implants, 37(2):270-282. https://doi.org/10.11607/jomi.9211https://doi.org/10.11607/jomi.9211
Liñares A, Sanz-Sánchez I, Dopico J, et al., 2023. Efficacy of adjunctive measures in the non-surgical treatment of peri-implantitis: a systematic review. J Clin Periodontol, 50(S26):224-243. https://doi.org/10.1111/jcpe.13821https://doi.org/10.1111/jcpe.13821
Lu HL, Tang HF, Zhou T, et al., 2018. Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system: a meta-analysis. Medicine, 97(13):e0248. https://doi.org/10.1097/MD.0000000000010248https://doi.org/10.1097/MD.0000000000010248
Mombelli A, Lang NP, 1992. Antimicrobial treatment of peri-implant infections. Clin Oral Implants Res, 3(4):162-168. https://doi.org/10.1034/j.1600-0501.1992.030402.xhttps://doi.org/10.1034/j.1600-0501.1992.030402.x
Park SH, Song YW, Cha JK, et al., 2021. Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: a multicenter randomized controlled trial. Clin Implant Dent Relat Res, 23(4):543-554. https://doi.org/10.1111/cid.13006https://doi.org/10.1111/cid.13006
Passarelli PC, Netti A, Lopez MA, et al., 2021. Local/topical antibiotics for peri-implantitis treatment: a systematic review. Antibiotics, 10(11):1298. https://doi.org/10.3390/antibiotics10111298https://doi.org/10.3390/antibiotics10111298
Polymeri A, van der Horst J, Anssari Moin D, et al., 2022. Non-surgical peri-implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial. Clin Oral Implants Res, 33(5):548-557. https://doi.org/10.1111/clr.13914https://doi.org/10.1111/clr.13914
Renvert S, Roos-Jansåker AM, Lindahl C, et al., 2007. Infection at titanium implants with or without a clinical diagnosis of inflammation. Clin Oral Implants Res, 18(4):509-516. https://doi.org/10.1111/j.1600-0501.2007.01378.xhttps://doi.org/10.1111/j.1600-0501.2007.01378.x
Rovai ES, Souto MLS, Ganhito JA, et al., 2016. Efficacy of local antimicrobials in the non-surgical treatment of patients with periodontitis and diabetes: a systematic review. J Periodontol, 87(12):1406-1417. https://doi.org/10.1902/jop.2016.160214https://doi.org/10.1902/jop.2016.160214
Santos RS, Macedo RF, Souza EA, et al., 2016. The use of systemic antibiotics in the treatment of refractory periodontitis: a systematic review. J Am Dent Assoc, 147(7):577-585. https://doi.org/10.1016/j.adaj.2016.02.013https://doi.org/10.1016/j.adaj.2016.02.013
Shibli JA, Ferrari DS, Siroma RS, et al., 2019. Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up. Braz Oral Res, 33(S1):e080. https://doi.org/10.1590/1807-3107bor-2019.vol33.0080https://doi.org/10.1590/1807-3107bor-2019.vol33.0080
Singh R, Sripada L, Singh R, 2014. Side effects of antibiotics during bacterial infection: mitochondria, the main target in host cell. Mitochondrion, 16:50-54. https://doi.org/10.1016/j.mito.2013.10.005https://doi.org/10.1016/j.mito.2013.10.005
Smeets R, Henningsen A, Jung O, et al., 2014. Definition, etiology, prevention and treatment of peri-implantitis ‒ a review. Head Face Med, 10:34. https://doi.org/10.1186/1746-160X-10-34https://doi.org/10.1186/1746-160X-10-34
Teughels W, Seyssens L, Christiaens V, et al., 2023. Adjunctive locally and systemically delivered antimicrobials during surgical treatment of peri-implantitis: a systematic review. J Clin Periodontol, 50(S26):359-372. https://doi.org/10.1111/jcpe.13773https://doi.org/10.1111/jcpe.13773
Verdugo F, Laksmana T, Uribarri A, 2016. Systemic antibiotics and the risk of superinfection in peri-implantitis. Arch Oral Biol, 64:39-50. https://doi.org/10.1016/j.archoralbio.2015.12.007https://doi.org/10.1016/j.archoralbio.2015.12.007
Vilarrasa J, Soldini MC, Pons R, et al., 2023. Outcome indicators of non-surgical therapy of peri-implantitis: a prospective case series analysis. Clin Oral Investig, 27(6):3125-3138. https://doi.org/10.1007/s00784-023-04918-2https://doi.org/10.1007/s00784-023-04918-2
Wang Y, Chen CY, Stathopoulou PG, et al., 2022. Efficacy of antibiotics used as an adjunct in the treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis. Int J Oral Maxillofac Implants, 37(2):235-249. https://doi.org/10.11607/jomi.9220https://doi.org/10.11607/jomi.9220
Yong JW, Gröger S, von Bremen J, et al., 2023. Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(11):957-973. https://doi.org/10.1631/jzus.B2200706https://doi.org/10.1631/jzus.B2200706
Zhang HD, Li WJ, Zhang L, et al., 2018. A nomogram prediction of peri-implantitis in treated severe periodontitis patients: a 1‒5-year prospective cohort study. Clin Implant Dent Relat Res, 20(6):962-968. https://doi.org/10.1111/cid.12686https://doi.org/10.1111/cid.12686
Zhao XT, Lin HB, Ding T, et al., 2023. Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(5):373-386. https://doi.org/10.1631/jzus.B2200576https://doi.org/10.1631/jzus.B2200576
Zhao YX, Pu R, Qian YJ, et al., 2021. Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: a systematic review and meta-analysis. Photodiagnosis Photodyn Ther, 34:102231. https://doi.org/10.1016/j.pdpdt.2021.102231https://doi.org/10.1016/j.pdpdt.2021.102231
Zitzmann NU, Berglundh T, Marinello CP, et al., 2001. Experimental peri-implant mucositis in man. J Clin Periodontol, 28(6):517-523. https://doi.org/10.1034/j.1600-051x.2001.028006517.xhttps://doi.org/10.1034/j.1600-051x.2001.028006517.x
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