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Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
吴迪.促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2023,24(12):1180-1184.
Di WU. Proapoptotic protein Bim regulates the suppressive function of Treg cells. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 24(12):1180-1184(2023)
吴迪.促凋亡蛋白质Bim调控Treg细胞的免疫抑制功能[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2023,24(12):1180-1184. DOI: 10.1631/jzus.B2300288.
Di WU. Proapoptotic protein Bim regulates the suppressive function of Treg cells. [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 24(12):1180-1184(2023) DOI: 10.1631/jzus.B2300288.
调节性T细胞(Treg细胞)是一种特殊的免疫抑制性CD4,+,-T淋巴细胞亚群,具有维持机体免疫稳态的重要作用。有研究证实,促凋亡蛋白Bim参与Treg细胞功能的调控,但是还没有使用条件性敲除小鼠对Bim在Treg细胞中功能研究的报道,且Treg细胞中Bim发挥功能的机制也不清楚。已知Bim在衰老的Treg细胞中丰度下调,然而该过程在Treg细胞衰老过程中的具体作用尚不清楚。本研究中,作者繁育产生,Foxp3,Cre,;,Bim,fl/fl,条件性敲除小鼠,特异性在Treg细胞中敲除,Bim,。,Foxp3,Cre,;,Bim,fl/fl,小鼠可育,但是出现多器官炎性细胞浸润和免疫细胞的过度激活,这表明Bim可以调节Treg细胞免疫抑制功能。,Bim,缺失导致Treg细胞转录组变化,以及,Ctla4,基因和多个信号通路的下调。Treg细胞中,Bim,的缺失可以抑制胆管癌的增殖,并延长胆管癌小鼠的生存期。,Bim,缺失的Treg细胞,不能复现衰老Treg细胞的转录组变化,这表明Bim的下调可能是Treg细胞衰老过程中的下游事件。
调节性T细胞Bim肿瘤免疫治疗免疫系统衰老
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